Gene therapy trial for skin cancer cures two terminal patients
">

Gene therapy trial for skin cancer cures two terminal patients

Friday, September 1, 2006

Melanoma is a type of skin cancer originating from the pigment cells of the skin, and has a poor prognosis when it’s not timely diagnosed and treated.

Results of gene therapy trials at the US National Cancer Institute, Bethesda to fight cancer published online yesterday by the scientific journal Science show some levels of success. However experts have warned that despite the promise more work is needed for this to become a viable cure.

Dr Stephen Rosenberg, who lead the research team, said “It’s important to emphasize this is a highly experimental treatment that’s still in the course of development.”

The team treated 17 terminal skin cancer patients with modified cells from their immune systems. The technique uses genetically modified white blood cells (more specifically T cells) to attack and kill the cancer cells. Of the 17 subjects only 2 were cured of the disease (an aggressive form of skin cancer called a melanoma which is usually fatal in advanced stages). Before the treatment, which lasted 18 months, the patients were only expected to live for up to 6 months. The remaining 15 patients were not affected by the treatment.

One of the successful patients was Mark Origer (53) from Wisconsin. He has been fighting cancer since first being diagnosed in 1999. After finding out about the new trial on the internet he applied and, after interviews, was accepted along with 16 other candidates. The treatment removed Origer’s melanoma and also shrunk another tumor in his liver – to the extent it could be removed surgically. Doctors confirmed he was free of the disease last week, nearly 2 years after treatment began. A second man (39) was cleared of his cancer which had spread to the lungs, liver and lymph nodes. Cancer that progresses to the lymph nodes is usually untreatable and fatal.

T cells can attack and destroy bacteria and other harmful cells like cancer cells. However cancer cells sometimes reduce the signals on their outer surface by which they are recognised, so the immune system cannot affect them. Gene therapy involves modifying some of a patients T cells to contain a new receptor. (Receptors are what enable the immune cell to identify harmful cells, like those corrupted by viruses. The new receptor is inserted with the use of a viral vector, i.e. a virus made safe to insert the receptor in the cell.

In the trial, T Cells were removed from each patient and modified in the laboratory. Patients underwent chemotherapy to kill most of their current immune system, which was replaced by the mutated cells. The modified cells successfully survived after injection into the body – making up 10% of the subject’s T cell count during the first 2 months. The team is now looking for ways to enable the cells to survive longer and in greater numbers.

Experts have called this a significant technical advance but warn that more patients need testing and the technique refining before any conclusive results can be drawn. Dr Edel O’Toole, consultant dermatologist and British Skin Foundation spokesman, said: “I think that the success of this approach in two patients shows promise, however 15 patients did not respond to the treatment suggesting that further work is needed to optimise this approach for all patients, which could take many years.”

Rosenberg now hopes to run a new trial with possibly stronger gene therapy treatments, he is currently awaiting FDA approval.

Gene therapy was much hyped after it’s first successful application in so called “bubble boys” (patients with severe combined immunodeficiency). After follow-up, these trials were stopped when it was discovered that three of eleven patients in one trial had developed leukemia.

Retrieved from “https://en.wikinews.org/w/index.php?title=Gene_therapy_trial_for_skin_cancer_cures_two_terminal_patients&oldid=717960”

New Jersey backpedals on proposed bikini waxing ban
">

New Jersey backpedals on proposed bikini waxing ban

Saturday, March 21, 2009

New Jersey has reversed its plans for a state-wide ban on bikini waxing after salon owners from across the state spoke out against the proposal.

The New Jersey Board of Cosmetology and Hairstyling planned to consider a ban on so-called “Brazilian waxes” in response to two women who reported being injured during a wax.

But state Consumer Affairs Director David Szuchman, who oversees the board, asked them to abandon the ban in favor of reviewing and establishing safeguards for those who provide the service.

“Many commentators have noted that the procedure could be safely performed,” Szuchman wrote in a letter to state board President Ronald Jerome Brown, according to the Asbury Park Press. “I, therefore, believe that there are alternative means to address any public health issues identified by the board.

Salon owners from across the state expressed relief with Szuchman’s decision.

“It was an unnecessary issue,” spa owner Linda Orsuto told the Associated Press. “In New Jersey especially, where the government has been picking our pockets for so long, it was like, ‘Just stay out of our pants, will you?'”

Although millions of Americans get bikini waxes, which generally cost between $50 and $60 per session, the practice comes with risks. Skin care experts say the hot wax can irritate delicate skin in the bikini area, and result in infections, ingrown hairs and rashes.

Waxing on the face, neck, abdomen, legs and arms are permitted in New Jersey. Although state statutes have always banned bikini waxing, the laws are seldom enforced because the wording is unclear.

If the measure had passed, New Jersey might have become the only US state to ban the practice outright.

Although Szuchman’s letter was crafted more as a recommendation than an order, media reports said the ban would likely never be approved without his support because his office oversees the board.

Retrieved from “https://en.wikinews.org/w/index.php?title=New_Jersey_backpedals_on_proposed_bikini_waxing_ban&oldid=793952”

Stuttering And Speech Therapy Ideas

Stuttering (or stammering) is a voice disfluency, a speech disorder. When a person stutters, the normal flow of speech is disrupted by repetitions and/or prolongations of voice sounds. Frequently, an individual is also unable to start a word.

Child stuttering, toddler stuttering and adult stuttering are themes being studied by many scientists and speech specialists all around the world. The Stuttering Foundation of America, the National Stuttering Association, the National Center for Stuttering and individual speech therapists in general are all investigating why people stutter and finding effective and fast speech therapies.

Nevertheless, even though scientists have several theories and suspect a variety of causes for stuttering, the precise mechanisms causing this disability (also called stammering) are not understood. Some believe that many forms have genetic origins.

A common form of stuttering is neurogenic. Neurogenic stuttering arise from signal problems between the brain and nerves or muscles. In neurogenic stuttering, the brain is unable to adequately coordinate the different components of speech mechanism.

The disruptions of speech may be accompanied by tremors of the lips and/or jaw, rapid eye blinks and other movements. This disorder commonly becomes more severe when speaking in front of a group of people or on the phone. On the other hand, speaking alone and singing might generally improve it or disappear completely.

Over three million Americans stutter. Stuttering affects all ages, but most frequently, children between the ages of 2 and 6 are the most affected. Preschool and toddler stuttering are especially affected while they are developing their language. When they grow up, most of them improve or cure. One percent or less of adults stutters.

Many famous people stutter. Marilyn Monroe, Bruce Willis, Winston Churchill and Mel Tillis are only a few whose success was not impeded by stuttering. Their speech language issue did not stop them to excel and express themselves magnificently.

With these encoraging news about famous people succeeding in spite of their common issue, I end part 1 of these series of articles. Much more information can be found at a site dedicated to stuttering problems and resources, as well as a library of speech language pathology.

This is the end of Part 1 of Stuttering and speech therapy ideas. On next chapters I will be writing about different and effective therapies developed lately by researchers on the field of stammering or speech language pathology.

Wikinews interviews 2020 Melbourne Lord Mayor Candidate Wayne Tseng
">

Wikinews interviews 2020 Melbourne Lord Mayor Candidate Wayne Tseng

This article mentions the Wikimedia Foundation, one of its projects, or people related to it. Wikinews is a project of the Wikimedia Foundation.

Thursday, October 22, 2020

2020 Melbourne Lord Mayor candidate Wayne Tseng answered some questions about his campaign for the upcoming election from Wikinews. The Lord Mayor election in the Australian city is scheduled to take place this week.

Portrait of Wayne TsengImage: Wayne Tseng.

Tseng runs a firm called eTranslate, which helps software developers to make the software available to the users. In the candidate’s questionnaire, Tseng said eTranslate had led to him working with all three tiers of the government. He previously belonged to the Australian Liberal Party, but has left since then, to run for mayorship as an independent candidate.

Tseng is of Chinese descent, having moved to Australia with his parents from Vietnam. Graduated in Brisbane, Tseng received his PhD in Melbourne and has been living in the city, he told Wikinews. Tseng also formed Chinese Precinct Chamber of Commerce, an organisation responsible for many “community bond building initiatives”, the Lord Mayor candidate told Wikinews.

Tseng discussed his plans for leading Melbourne, recovering from COVID-19, and “Democracy 2.0” to ensure concerns of minorities in the city were also heard. Tseng also focused on the importance of the multi-culture aspect and talked about making Melbourne the capital of the aboriginals. Tseng also explained why he thinks Melbourne is poised to be a world city by 2030.

Tseng’s deputy Lord Mayor candidate Gricol Yang is a Commercial Banker and works for ANZ Banking Group.

Currently, Sally Capp is the Lord Mayor of Melbourne, the Victorian capital. Capp was elected as an interim Lord Mayor in mid-2018 after the former Lord Mayor Robert Doyle resigned from his position after sexual assault allegations. Doyle served as the Lord Mayor of Melbourne for almost a decade since 2008.

Retrieved from “https://en.wikinews.org/w/index.php?title=Wikinews_interviews_2020_Melbourne_Lord_Mayor_Candidate_Wayne_Tseng&oldid=4598699”

China overtakes Germany as world’s biggest exporter
">

China overtakes Germany as world’s biggest exporter

Sunday, January 10, 2010

Chinese officials have said that their country’s exports surged last December to edge out Germany as the world’s biggest exporter.

The official Xinhua news agency reported today that figures from the General Administration for Customs showed that exports jumped 17.7% in December from a year earlier. Over the whole of 2009 total Chinese exports reached US$1.2 trillion, above Germany’s forecast $1.17 trillion.

Huang Guohua, a statistics official with the customs administration, said the December exports rebound was an important turning point for China’s export sector. He commented that the jump was an indication that exporters have emerged from their downslide.

“We can say that China’s export enterprises have completely emerged from their all-time low in exports,” he said.

However, although China overtook Germany in exports, China’s total foreign trade — both exports and imports — fell 13.9% last year.

Retrieved from “https://en.wikinews.org/w/index.php?title=China_overtakes_Germany_as_world%27s_biggest_exporter&oldid=3255271”

University of Wales to close down after 120 years
">

University of Wales to close down after 120 years

Saturday, October 22, 2011

120 years after it was founded, the University of Wales (UoW) will shut down. Already comprised of several institutions, two will merge fully while two more will become independent universities.

With a charter from 1893 and the Prince of Wales as its chancellor, problems began at UoW last year after concerns the head of a Malaysian partner institution, a local pop artist, had non-legitimate qualifications. This was followed by Thailand’s authorities denouncing another UoW partner as illegal, then an investigation in the UK into all the UoW’s foreign ties.

The Quality Assurance Agency said UoW’s overseas checks on foreign institutions were inadequate. The UK Border Agency is investigating a possible visa scam whereby foreign students were sold exam answers for a qualification leading to UoW entry and British visas. Two colleges — Rayat London College and Lampton College — are suspended over the claims.

Trinity St David and Swansea Metropolitan universities are to merge, forming University of Wales: Trinity St David. It is to use the latter’s own royal charter, which is itself 190 years old. Newport and Glyndwr are set to become universities in their own right. The dissolution follows calls from the leaders of rival universities for the end of UoW.

“I warmly welcome the historic decision taken today by the University of Wales Council,” said UoW Vice-Chancellor Professor Medwin Hughes, who will fill the same role for the new University of Wales: Trinity St David. “The transformed University will serve and deliver for Wales.” His counterpart for Newport, Dr Peter Noyes, said “The inevitable end to the story of the University of Wales should not detract from a distinguished history lasting 12 decades. Wales should be sad that this day has come[.]” UoW chairmain Hugh Thomas has resigned.

The Prince of Wales is among past students, having spent a 1969 term there. The institution’s various member organisations at one point included the now-separate Cardiff University.

Retrieved from “https://en.wikinews.org/w/index.php?title=University_of_Wales_to_close_down_after_120_years&oldid=3356560”

Professional Personal Assistants For Homes

Professional Personal Assistants for Homes

by

BSLMnyc

Those who visit New York City frequently in connection with their business or any other activity or those who have an apartment in the city require the service of somebody in order to take care of their day-to-day requirements. The personal assistant, New York will be helpful to such people in all the activities such as maintaining the apartment, carry out the repairs and renovations, arranging various entertainments and appointments, making arrangements for travel inside the US as well as abroad and taking care of the house in the absence of the house owner etc. There are numerous service providers in New York who provide this type of domestic staff to their clients. They always provide the ideal candidate who will be well trained and able to meet the requirements of the person who needs his service. Though these domestic employees are highly professional, they also develop intimacy with their employer. The celebrities, doctors, lawyers and leading businessmen often require the services of a professional to attend their phones, fix the appointments, meet their urgent requirements of coffee, medicines, transport etc.

Personnel assistant, New York is generally a full-time job and the persons opting for this position must be flexible to work overtime also. They are entitled for two holidays in a week and the remuneration package also is quite attractive. Their nature of job depends upon the occupation of their principals and their requirements. They will be required to handle both business and personal matters of the principals. They have to arrange events, social gatherings, dinners and personal visits etc. They have to supervise and co-ordinate with other domestic staff. They have to monitor the domestic expenses and give periodic statements to the principals. Sometimes, they are required to act as gate keepers also. Those who work under leading businessmen or industrialists will have to book flight tickets and make arrangement for the travel of their principals.

[youtube]http://www.youtube.com/watch?v=MLghoWe0tVA[/youtube]

The well educated and experienced staff will be asked to take care of correspondence also. They may have to draft mails and attend visitors and telephone calls. They have to go for shopping also and special or urgent requirements of their principals are to be met. The candidates for these positions are expected to have good communication skills and must be able to work independently. They must possess organizing skills and should have working knowledge of computers. Those who have professional approach, flexibility and willingness to work hard in a domestic atmosphere can easily prosper in this job. The candidate should have a degree.

This content has been taken from http://www.ideamarketers.com/?articleid=3276709&CFID=182994039&CFTOKEN=71279402

We have the largest online resource that provides personal assistance to keep good lifestyle.

personal assistant service

helps customers maintain a group of assistants with experience to offer our customers added organization involved in their lives. For more information on

personal assistants nyc

, visit our site.

Article Source:

ArticleRich.com

Ford’s US auto sales spike, surpassing GM
">

Ford’s US auto sales spike, surpassing GM

Wednesday, March 3, 2010

Ford Motor Company said on Tuesday that its sales in the United States rose 43% in February compared to the same period last year, as the automaker outsold rivals Toyota and General Motors.

The strength of our new products … are resonating with customers

Ford said that total sales improved to 142,285 units, compared to 141,951 units sold by GM. Additionally, Ford said that its share of the total US car market rose to 17%, up from 14% a year ago. The increase was better than analysts had predicted, and Ford’s stock rose to a five-year high in morning trading, before declining later in the day. Ford’s sales were significantly influenced by a 74% increase in fleet sales to businesses. Rental car agencies alone accounted for around 30,000 units sold. Sales to retail consumers increased only 28%.

The increases were led by sales of two sedans, the Fusion and Taurus, which rose 166.5 and 93.3% respectively, although sales of other models such as SUVs and pickup trucks also increased. Both models were significantly redesigned last year, and analysts said that improved quality from such cars were driving the increases.

Other companies also reported February sales today, nearly all reporting sales gains as well, although none as large as those of Ford. Toyota was the sole exception to the sales gains, as their sales declined 8.7%, as the company was faced with a global recall during the month that led to a temporary stoppage of production for some models.

“The strength of our new products … are resonating with customers,” said Ken Czubay, Ford’s vice president of sales and marketing. However, he believed that traditional Toyota customers were not buying rival autos, but rather awaiting the results from the recalls.

Retrieved from “https://en.wikinews.org/w/index.php?title=Ford%27s_US_auto_sales_spike,_surpassing_GM&oldid=2715048”

Food with cancer-causing dye recalled in Britain
">

Food with cancer-causing dye recalled in Britain

Saturday, April 30, 2005

The British Food Standards Agency (FSA) has announced a recall of foods containing banned dyes which increase the risk of cancer. The food products were sold at the Tesco, Waitrose, and Somerfield supermarkets.

A Bristol company called “Barts Spices” found the illegal Para Red substance in their Barts Ground Paprika, which was sold in 48g and 46g jars with a “Co-op” label. The batch codes on the affected products are 5032 and 5089 (expiration Dec 2007), and 5075 (expiration February 2007).

Tesco also found that their 130g package of BBQ rice cakes (expiration November and December 2005) contained both Para Red and Sudan I.

“It would be very prudent to assume that it could be a genotoxic carcinogen,” FSA scientific advisers told reporters.

“As a company committed to supplying only the very finest quality food ingredients, we took the immediate decision to withdraw our ground paprika spice from all outlets selling the product and advertised a product recall in the national press,” a Barts Spices spokesman said in a statement.

Sudan I is only authorized for industrial use to colorize petroleum products, such as shoe polish. Para Red and Sudan I are banned under the British Colours in Food Regulations of 1995.

Britain last went through a major food recall in February, when Worcester Sauce was found to contain chili powder dyed with Sudan 1.

Retrieved from “https://en.wikinews.org/w/index.php?title=Food_with_cancer-causing_dye_recalled_in_Britain&oldid=1972969”

Wikinews interviews Amber Merritt Australian Paralympic wheelchair basketballer
">

Wikinews interviews Amber Merritt Australian Paralympic wheelchair basketballer

Thursday, September 6, 2012

Amber Merritt changing a wheel in the game against Mexico. Image: Laura Hale.

London, England— Tuesday, following her team’s 62–37 win over Mexico in the quarter-finals at the North Greewich Arena, Wikinews interviewed Amber Merrit of the Australian women’s national wheelchair basketball team.

In their next match, the Gliders will face the victors from the United States versus Canada, having suffered their first loss of this year’s Games to Canada on Sunday night by seven points.

((Laura Hale)) I’m excited to see you in London, because you were so fantastic in that interview.

[Wikinews previously interviewed Merrit, and teammates in July. —Ed.]

Amber Merrit: Thank you.

((WN)) Which state are you from?

AM: I’m from WA. [Western Australia —Ed.]

((WN)) You wheel change! What was wrong with your wheel?

AM: I smashed out three spokes. Someone hit me, and I lost three spokes in my chair.

((WN)) was that because you were playing really aggressively against Mexico?

AM: Yeah, or they were playing really aggressive against us.

((WN)) Watching that game it didn’t seem that they were playing that aggressive, in terms of they came in with set pieces; they weren’t doing the full-court press; they didn’t seem prepared for your offensive and defensive tenacity. ((Hawkeye7)) You kept on all holding them out, where they weren’t even getting across the centre line

AM: I think we have a really physical style of basketball where we’re going to press, and when we press we try to stop chairs and make sure they don’t get over that halfway line. They’re going to come out and play as hard as they can against us and sometimes there is that odd mishap where they might smash a few spokes cause they hit us. It happens.

((WN)) You tipped a lot in previous games. You haven’t tipped so much in this series.

AM: No, I’ve managed to keep my balance this time. Or maybe they haven’t hit me hard enough to put me down on the floor.

((WN)) Part of the appeal of wheelchair basketball, and I feel guilty admitting it, it watching you guys tip.

AM: And fall out. It’s embarrassing but I like it.

((WN)) You’ve got your next game coming up, which is going to be against the winner of the United States or Canada later today

AM: We’re not 100% sure yet who that’s going to be.

((WN)) Looking forward to meeting them?

AM: Yeah! Looking forward to coming up against them.

((WN)) Who would you prefer?

AM: I don’t know if I have a preference, to be honest. Whoever its going to be, we’re still going to go out there and play as hard as we can and take it to them as a team.

((WN)) Do you think you’ve been adequately prepared coming in to this, with your tournament in Sydney, your tournament in the Netherlands?

AM: Yeah, I think we’ve come in very well prepared for this tournament. We’ve been together for a while now as a team. Of course we had the Gliders and Rollers world challenge. We also went to Arnheim in the Netherlands for a pre-tournament, and we’ve trained together in Cardiff. And then after Cardiff we came in to London; so we’ve had that time together as a team and we’re doing really well.

((WN)) Does that give you an advantage over other teams?

AM: I’m not sure, because I don’t know what other teams have been doing behind the scenes as their training.

((WN)) Thank you very much.

AM: No worries!
Retrieved from “https://en.wikinews.org/w/index.php?title=Wikinews_interviews_Amber_Merritt_Australian_Paralympic_wheelchair_basketballer&oldid=2708758”

« Previous Entries Next Entries »